You should visit your doctor monthly to check how you are doing on this medication.

If you get any of the following symptoms while you are taking ACCUTANE^™, you must tell your doctor immediately because it may be necessary to stop ACCUTANE:

• You get pregnant, or get pregnant within one month after stopping ACCUTANE
• Changes in your mood such as becoming depressed, feeling sad, or having crying spells, and/or other signs of mental health problems such as:
  • Losing interest in your usual activities
  • Changes in your normal sleep patterns
  • Becoming more irritable or aggressive than usual (for example, temper outbursts, thoughts of violence)
  • Losing your appetite
  • Becoming unusually tired
  • Having trouble concentrating
  • Withdrawing from family and friends
  • Having thoughts about taking your own life (suicidal thoughts)
• Blisters, peeling skin, severe red/purple rash, multiple lesions and sores, particularly in your mouth, nose, eyes and genitals, as well as facial and tongue swelling
• Bad headaches, blurred vision, dizziness, nausea, vomiting
• Severe stomach pain, diarrhea, rectal bleeding
• Yellowing of the skin or eyes and/or dark urine
• Changes in your hearing or ringing in your ears
• Changes in your vision, especially at night; decreased night vision may occur and be sudden in some patients; take caution when driving at night
• Persistently dry eyes
• Aches or pains in bones or joints, back pain, difficulty in moving, or muscle pain, especially after vigorous exercise – if a bone breaks, tell your doctor
• Hives, swollen face or mouth, trouble breathing, fever, rash, red patches, bruises
• Fainting, become very thirsty, urinating a lot, feeling weak
• Chest pain, palpitations, vascular thrombotic disease, stroke
• Leg swelling, seizures (convulsions), slurred speech, problems moving or any other serious unusual problems
• Your acne becomes worse

Questions or concerns about taking ACCUTANE?
Please refer to the Consumer Information document for more information.

Talk to your doctor or call 1-888-XEDITON (933-4866).